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大鼠五孔注意力测试系统基于视觉上的辨别力，通过运行5-CSRTT任务(5-choice serial reaction time task)， 测试动物的注意力、冲动性(impulsivity)等一系列行为学指标，主要用于注意力缺失/多动综合症(attention deficit/hyperactivity disorder, ADHD)、老年痴呆(Alzheimer’s disease)、精神分裂症(Schizophrenia)等精神疾病研究。
The 5-hole box can be used to run 5-choice serial reaction time task (5-CSRT).
The 5-CSRT has been used for measuring effects of systemic drug treatments and also central manipulations such as neurochemical
lesions on various aspects of attentional control,including sustained, selective and divided attention – and is relevant to the definition of neural systems of attention and applications to human disorders such as attention deficit/hyperactivity disorder (ADHD) and Alzheimer’s disease.
The 5-CSRT is implemented in a specially designed operant chamber with multiple response locations (’five-hole box’) using food reinforcers to maintain performance on baseline sessions (about 100 trials) at criterion levels of accuracy and trials completed. The 5-CSRT can be used for measuring various aspects of attentional control over performance with its main measures of accuracy, premature responding, correct response latencies and latency to collect earned food pellets.
References:
Robbins TW. The 5-choice serial reaction time task: behavioural pharmacology
and functional neurochemistry. Psychopharmacology (2002) 163:362-380
Chudasama Y, Robbins TW. Psychopharmacological approaches to modulating attention
in the five-choice serial reaction time task: implications for schizophrenia. Psychopharmacology (2004) 174: 86–98
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